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ResearchIn-Press PreviewImmunologyInfectious disease Open Access | 10.1172/JCI176142
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Desai, J. in: JCI | PubMed | Google Scholar |
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Zarakas, M. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Wishart, A. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Roschewski, M. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Aufiero, M. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Donkó, Á. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Wigerblad, G. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Shlezinger, N. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Plate, M. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by James, M. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Lim, J. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Uzel, G. in: JCI | PubMed | Google Scholar |
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Bergerson, J. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Fuss, I. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Cramer, R. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Franco, L. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Clark, E. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Khan, W. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Yamanaka, D. in: JCI | PubMed | Google Scholar |
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Chamilos, G. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by El-Benna, J. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Kaplan, M. in: JCI | PubMed | Google Scholar |
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Staudt, L. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Leto, T. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Holland, S. in: JCI | PubMed | Google Scholar |
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Wilson, W. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Hohl, T. in: JCI | PubMed | Google Scholar
1Fungal Pathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
2Lymphoid Malignancies Branch, National Cancer Institute, NIH, Bethesda, United States of America
3Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, United States of America
4Molecular Defenses Section, LCIM, NIAID, NIH, Bethesda, United States of America
5Systemic Autoimmunity Branch, NIAMS, NIH, Bethesda, United States of America
6Infectious Diseases, Memorial Sloan Kettering Cancer Center, New York, United States of America
7Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, United States of America
8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Immunopathogenesis Section, LCIM, NIAID, NIH, Bethesda, United States of America
10Primary Immune Deficiency Clinic, LCIM, NIAID, NIH, Bethesda, United States of America
11Mucosal Immunity Section, LCIM, NIAID, NIH, Bethesda, United States of America
12Functional Immunogenomics Section, NIAMS, NIH, Bethesda, United States of America
13Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, United States of America
14Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
15Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Greece
16Center for Research on Inflammation, City University of Paris, INSERM-U1149, CNRS-ERL8252, Paris, France
Find articles by Lionakis, M. in: JCI | PubMed | Google Scholar |
Published May 2, 2024 - More info
We describe a previously-unappreciated role for Bruton's tyrosine kinase (BTK) in fungal immune surveillance against aspergillosis, an unforeseen complication of BTK inhibitors (BTKi) used for treating B-cell lymphoid malignancies. We studied BTK-dependent fungal responses in neutrophils from diverse populations, including healthy donors, BTKi-treated patients, and X-linked agammaglobulinemia patients. Upon fungal exposure, BTK was activated in human neutrophils in a TLR2-, Dectin-1-, and FcγR-dependent manner, triggering the oxidative burst. BTK inhibition selectively impeded neutrophil-mediated damage to Aspergillus hyphae, primary granule release, and the fungus-induced oxidative burst by abrogating NADPH oxidase subunit p40phox and GTPase RAC2 activation. Moreover, neutrophil-specific Btk deletion in mice enhanced aspergillosis susceptibility by impairing neutrophil function, not recruitment or lifespan. Conversely, GM-CSF partially mitigated these deficits by enhancing p47phox activation. Our findings underline the crucial role of BTK signaling in neutrophils for antifungal immunity and provide a rationale for GM-CSF use to offset these deficits in susceptible patients.