[CITATION][C] Abrogation of Graft‐versus‐Host Disease Following Allotransplantation of Cytotoxically Deficient Bone Marrow across Major Histocompatibility Barriers
G Selvaggi, L Inverardi, RB Levy… - Annals of the New …, 1995 - Wiley Online Library
G Selvaggi, L Inverardi, RB Levy, MD Brendel, J Spielman, DH Mintz, ER Podack, C Ricordi
Annals of the New York Academy of Sciences, 1995•Wiley Online LibraryRESULTS In the first set of experiments, BALB/c mice were reconstituted 24 hours
postirradiation (9.25 Gy) with 4 x lo7 bone marrow cells (BMC). Recipients of B6 P+/+ BMC
developed lethal GVHD with an onset of clinical signs (weight loss, diarrhea, dermatitis,
hunchback position, and fur loss) starting 2-3. weeks after bone marrow transplantation
(BMT); the disease progressed, leading to the death of all animals within 64 days
posttransplant (TABLE 1). Histopathological assessment of the specimens derived from the …
postirradiation (9.25 Gy) with 4 x lo7 bone marrow cells (BMC). Recipients of B6 P+/+ BMC
developed lethal GVHD with an onset of clinical signs (weight loss, diarrhea, dermatitis,
hunchback position, and fur loss) starting 2-3. weeks after bone marrow transplantation
(BMT); the disease progressed, leading to the death of all animals within 64 days
posttransplant (TABLE 1). Histopathological assessment of the specimens derived from the …
RESULTS
In the first set of experiments, BALB/c mice were reconstituted 24 hours postirradiation (9.25 Gy) with 4 x lo7 bone marrow cells (BMC). Recipients of B6 P+/+ BMC developed lethal GVHD with an onset of clinical signs (weight loss, diarrhea, dermatitis, hunchback position, and fur loss) starting 2-3. weeks after bone marrow transplantation (BMT); the disease progressed, leading to the death of all animals within 64 days posttransplant (TABLE 1). Histopathological assessment of the specimens derived from the affected animals showed marked mononuclear infiltration in
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