Bid-induced cytochrome c release is mediated by a pathway independent of mitochondrial permeability transition pore and Bax
TH Kim, Y Zhao, MJ Barber, DK Kuharsky… - Journal of Biological …, 2000 - ASBMB
Bid, a pro-apoptosis" BH3-only" member of the Bcl-2 family, can be cleaved by caspase-8
after Fas/TNF-R1 engagement. The p15 form of truncated Bid (tBid) translocates to
mitochondria and induces cytochrome c release, leading to the activation of downstream
caspases and apoptosis. In the current study, we investigated the mechanism by which tBid
regulated cytochromec release in terms of its relationship to mitochondrial permeability
transition and Bax, another Bcl-2 family protein. We employed an in vitro reconstitution …
after Fas/TNF-R1 engagement. The p15 form of truncated Bid (tBid) translocates to
mitochondria and induces cytochrome c release, leading to the activation of downstream
caspases and apoptosis. In the current study, we investigated the mechanism by which tBid
regulated cytochromec release in terms of its relationship to mitochondrial permeability
transition and Bax, another Bcl-2 family protein. We employed an in vitro reconstitution …
