[HTML][HTML] Involvement of protein kinase Cε (PKCε) in thyroid cell death: a truncated chimeric PKCε cloned from a thyroid cancer cell line protects thyroid cells from …
JA Knauf, R Elisei, D Mochly-Rosen, T Liron… - Journal of Biological …, 1999 - ASBMB
The protein kinase C (PKC) family has been implicated in the regulation of apoptosis.
However, the contribution of individual PKC isozymes to this process is not well understood.
We reported amplification of the chromosome 2p21 locus in 28% of thyroid neoplasms, and
in the WRO thyroid carcinoma cell line. By positional cloning we identified a rearrangement
and amplification of the PKCε gene, that maps to 2p21, in WRO cells. This resulted in the
overexpression of a chimeric/truncated PKCε (Tr-PKCε) mRNA, coding for N-terminal amino …
However, the contribution of individual PKC isozymes to this process is not well understood.
We reported amplification of the chromosome 2p21 locus in 28% of thyroid neoplasms, and
in the WRO thyroid carcinoma cell line. By positional cloning we identified a rearrangement
and amplification of the PKCε gene, that maps to 2p21, in WRO cells. This resulted in the
overexpression of a chimeric/truncated PKCε (Tr-PKCε) mRNA, coding for N-terminal amino …
