[HTML][HTML] Dietary Fat Elevates Hepatic ApoA-I Production by Increasing the Fraction of Apolipoprotein AI mRNA in the Translating Pool (∗)
N Azrolan, H Odaka, JL Breslow, EA Fisher - Journal of Biological …, 1995 - ASBMB
Elevated plasma high density lipoprotein cholesterol (HDL-C) levels are associated with a
decreased risk for coronary heart disease. Ironically, diets enriched in saturated fat and
cholesterol (HF/HC diets), which tend to accelerate atherosclerotic processes by increasing
LDL cholesterol levels, also raise HDL-C. We have recently reported, using a human apoA-I
(hapoA-1) transgenic mouse model, that the elevation of HDL-C by a HF/HC diet is
attributable, in part, to an increase in the hepatic production of hapoA-1. To further define the …
decreased risk for coronary heart disease. Ironically, diets enriched in saturated fat and
cholesterol (HF/HC diets), which tend to accelerate atherosclerotic processes by increasing
LDL cholesterol levels, also raise HDL-C. We have recently reported, using a human apoA-I
(hapoA-1) transgenic mouse model, that the elevation of HDL-C by a HF/HC diet is
attributable, in part, to an increase in the hepatic production of hapoA-1. To further define the …
