1, 25-dihydroxyvitamin D3 inhibits proliferation of human promyelocytic leukaemia (HL60) cells and induces monocyte-macrophage differentiation in HL60 and normal …
DM McCarthy, JF San Miguel, HC Freake, PM Green… - Leukemia research, 1983 - Elsevier
dihydroxyvitamin D 3 induces monocyte-macrophage differentiation and inhibits proliferation
of cells from the human promyelocytic leukaemia cell line HL60. Similarly human bone
marrow progenitor cells differentiate preferentially along the monocyte-macrophage
pathway when incubated in the presence of 1, 25-dihydroxyvitamin D 3. We suggest that the
inhibition of growth which occurs after addition of the vitamin to HL60 might be paralleled in
vivo by inhibition of proliferation of leukaemic cells; also we speculate that the vitamin may …
of cells from the human promyelocytic leukaemia cell line HL60. Similarly human bone
marrow progenitor cells differentiate preferentially along the monocyte-macrophage
pathway when incubated in the presence of 1, 25-dihydroxyvitamin D 3. We suggest that the
inhibition of growth which occurs after addition of the vitamin to HL60 might be paralleled in
vivo by inhibition of proliferation of leukaemic cells; also we speculate that the vitamin may …