The role of the vitamin D endocrine system in health and disease

H Reichel, HP Koeffler… - New England Journal of …, 1989 - Mass Medical Soc
H Reichel, HP Koeffler, AW Norman
New England Journal of Medicine, 1989Mass Medical Soc
The secosteroid hormone 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3) is the major
biologically active metabolite of vitamin D3.(Secosteroids are those in which one of the rings
has undergone fission; in vitamin D, this is ring B.) 1, 25 (OH) 2D3 is recognized as the
principal mediator within the sphere of action of vitamin D in the regulation of bone and
mineral metabolism in humans. 1 2 3 Recent evidence has suggested a wider biologic role
of 1, 25 (OH) 2D3 in tissues not primarily related to mineral metabolism. Vitamin D …
The secosteroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the major biologically active metabolite of vitamin D3. (Secosteroids are those in which one of the rings has undergone fission; in vitamin D, this is ring B.) 1,25(OH)2D3 is recognized as the principal mediator within the sphere of action of vitamin D in the regulation of bone and mineral metabolism in humans.1 2 3 Recent evidence has suggested a wider biologic role of 1,25(OH)2D3 in tissues not primarily related to mineral metabolism.
Vitamin D Metabolism
Metabolic Activation
An overview of vitamin D . . .
The New England Journal Of Medicine