HLA-DQ beta-chain polymorphism linked to myasthenia gravis
J Bell, S Smoot, C Newby, K Toyka, L Rassenti, K Smith… - The Lancet, 1986 - Elsevier
J Bell, S Smoot, C Newby, K Toyka, L Rassenti, K Smith, R Hohlfeld, H McDevitt, L Steinman
The Lancet, 1986•ElsevierThe HLA-DR3 haplotype is associated with increased risk of myasthenia gravis (MG) and a
number of other autoimmune diseases, including insulin-dependent diabetes mellitus
(IDDM), coeliac disease, and premature ovarian failure (POF). With a cDNA probe for a DQ
beta gene, a 15 kb Hinc II restriction fragment has been demonstrated in genomic DNA from
7 of 16 HLA-DR3 patients with MG, 1 of 19 healthy DR3 controls, and none of 24 DR3
patients with IDDM, coeliac disease, or POF. The HLA-DQ polymorphism may be closely …
number of other autoimmune diseases, including insulin-dependent diabetes mellitus
(IDDM), coeliac disease, and premature ovarian failure (POF). With a cDNA probe for a DQ
beta gene, a 15 kb Hinc II restriction fragment has been demonstrated in genomic DNA from
7 of 16 HLA-DR3 patients with MG, 1 of 19 healthy DR3 controls, and none of 24 DR3
patients with IDDM, coeliac disease, or POF. The HLA-DQ polymorphism may be closely …
Abstract
The HLA-DR3 haplotype is associated with increased risk of myasthenia gravis (MG) and a number of other autoimmune diseases, including insulin-dependent diabetes mellitus (IDDM), coeliac disease, and premature ovarian failure (POF). With a cDNA probe for a DQ beta gene, a 15 kb Hinc II restriction fragment has been demonstrated in genomic DNA from 7 of 16 HLA-DR3 patients with MG, 1 of 19 healthy DR3 controls, and none of 24 DR3 patients with IDDM, coeliac disease, or POF. The HLA-DQ polymorphism may be closely linked to a genetic locus regulating immune responsiveness to acetylcholine receptor and susceptibility to MG.
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