Sterol-modulated glycolipid sorting occurs in Niemann-Pick C1 late endosomes
M Zhang, NK Dwyer, EB Neufeld, DC Love… - Journal of Biological …, 2001 - ASBMB
The Niemann-Pick C1 (NPC1) protein and endocytosed low density lipoprotein (LDL)-
derived cholesterol were shown to enrich separate subsets of vesicles containing lysosomal
associated membrane protein 2. Localization of Rab7 in the NPC1-containing vesicles and
enrichment of lysosomal hydrolases in the cholesterol-containing vesicles confirmed that
these organelles were late endosomes and lysosomes, respectively. Lysobisphosphatidic
acid, a lipid marker of the late endosomal pathway, was found in the cholesterol-enriched …
derived cholesterol were shown to enrich separate subsets of vesicles containing lysosomal
associated membrane protein 2. Localization of Rab7 in the NPC1-containing vesicles and
enrichment of lysosomal hydrolases in the cholesterol-containing vesicles confirmed that
these organelles were late endosomes and lysosomes, respectively. Lysobisphosphatidic
acid, a lipid marker of the late endosomal pathway, was found in the cholesterol-enriched …
