A new member of the acid-sensing ion channel family
Acid-sensing ion channels (ASICs) are members of the epithelial sodium channel (ENaC)-
degenerin family of two-pass transmembrane segment protein subunits which form multi-
meric cation channels. Members of the ENaC-degenerin family are gated by stimuli as
diverse as protons, peptides and mechanical distension. Here we describe a new member
of the family, SPASIC or ASIC 4 (spinal cord ASIC) which is expressed throughout the
central nervous system in an overlapping population of neurons that also express the ASIC …
degenerin family of two-pass transmembrane segment protein subunits which form multi-
meric cation channels. Members of the ENaC-degenerin family are gated by stimuli as
diverse as protons, peptides and mechanical distension. Here we describe a new member
of the family, SPASIC or ASIC 4 (spinal cord ASIC) which is expressed throughout the
central nervous system in an overlapping population of neurons that also express the ASIC …
