An inhibitor of activated thrombin-activatable fibrinolysis inhibitor potentiates tissue-type plasminogen activator-induced thrombolysis in a rabbit jugular vein …
M Nagashima, M Werner, M Wang, L Zhao, DR Light… - Thrombosis research, 2000 - Elsevier
When activated in vitro, thrombin-activatable fibrinolysis inhibitor (TAFI) slows clot lysis by
cleaving the C-terminal lysine and arginine residues from partially degraded fibrin. An
inhibitor of carboxypeptidase isolated from potato (CPI) reverses prolongation of clot lysis by
inhibiting activated TAFI. We investigated in vivo effect of TAFI inhibition on tissue-type
plasminogen activator (t-PA)-induced clot lysis using CPI in a rabbit jugular vein
thrombolysis model. It was found necessary to further purify the CPI preparations from …
cleaving the C-terminal lysine and arginine residues from partially degraded fibrin. An
inhibitor of carboxypeptidase isolated from potato (CPI) reverses prolongation of clot lysis by
inhibiting activated TAFI. We investigated in vivo effect of TAFI inhibition on tissue-type
plasminogen activator (t-PA)-induced clot lysis using CPI in a rabbit jugular vein
thrombolysis model. It was found necessary to further purify the CPI preparations from …
