Expression of low-affinity Fc gamma receptor by a human metastatic melanoma line
L Cassard, MA Dragon-Durey, A Ralli, E Tartour… - Immunology …, 2000 - Elsevier
The class IIa of low-affinity receptors for the Fc region of IgG, FcγRIIa, are expressed on
immune cells. The cross-linking of FcγRIIa by complexed IgG triggers activation of protein
tyrosine kinase and internalization of immune complexes. In this report, we demonstrate the
expression of FcγRIIa by a human melanoma cell line (VIO) derived from a metastasis of a
patient with regressive melanoma. The analysis of FcγRIIa functions was performed in VIO
cells and FcγRIIa-or FcγRIIb-transfected human melanoma cells (A375). The FcγRIIa cross …
immune cells. The cross-linking of FcγRIIa by complexed IgG triggers activation of protein
tyrosine kinase and internalization of immune complexes. In this report, we demonstrate the
expression of FcγRIIa by a human melanoma cell line (VIO) derived from a metastasis of a
patient with regressive melanoma. The analysis of FcγRIIa functions was performed in VIO
cells and FcγRIIa-or FcγRIIb-transfected human melanoma cells (A375). The FcγRIIa cross …
