Ion transport across the murine intestine in the absence and presence of CFTR
BR Grubb - Comparative Biochemistry and Physiology Part A …, 1997 - Elsevier
CF mice, ie, mice without functional CFTR (cystic fibrosis transmembrane conductance
regulator) exhibit a very low basal Isc in all regions of the intestinal tract. The low basal Isc in
the intestinal epithelia of the CF mice appears to be a result of lack of spontaneous Cl−
secretion (and possibly HCO3− secretion) mediated by neurotransmitter release from the
enteric nervous system. In contrast to intestinal epithelia from normal mice, the intestinal
epithelia of CF mice do not secrete Cl− in response to agents that increase cAMP (forskolin) …
regulator) exhibit a very low basal Isc in all regions of the intestinal tract. The low basal Isc in
the intestinal epithelia of the CF mice appears to be a result of lack of spontaneous Cl−
secretion (and possibly HCO3− secretion) mediated by neurotransmitter release from the
enteric nervous system. In contrast to intestinal epithelia from normal mice, the intestinal
epithelia of CF mice do not secrete Cl− in response to agents that increase cAMP (forskolin) …