Insulin has a plethora of actions, most of which are initiated after interaction with its specific
cell surface receptor on classical target tissues. Prominent among these actions is its ability
to increase cellular permeability to glucose in muscle and fat. Heretofore, the cardiovascular
actions of insulin in humans have received little attention. The effects of insulin on the
cardiovascular system and, in particular, on skeletal muscle vasculature are physiological,
specific, co-ordinated and appear to play an integral part in its overall action to promote the …