been improved by a number of recent advances. Diagnosis of hormone hypersecretion has been facilitated by the development of more sensitive and reliable assays, especially for ACTH and insulin-like growth factor I (IGF)-I. Pituitary tumors can now be visualized more accurately due to continued improvements in magnetic resonance imaging (MRI) techniques with gadolinium enhancement. Petrosal sinus sampling can be used to measure hormone levels in the venous blood draining the pituitary. This has proved helpful in the differential diagnosis of Cushing’s disease. Treatment of pituitary tumors has been improved by advances in transsphenoidal surgery and radiotherapy and by the development of remarkably effective drugs for PRL and GH-secreting tumors. The primary therapeutic objectives are to normalize levels of hypersecreted hormones and to reduce tumor size to prevent damage to normal pituitary tissue and surrounding parasellar structures, especially the optic chiasm. This short review describes our current approach to the diagnosis and treatment of hormone-and nonhormone-secreting pituitary tumors.