Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA
CE Pearson, RR Sinden - Current opinion in structural biology, 1998 - Elsevier
CE Pearson, RR Sinden
Current opinion in structural biology, 1998•ElsevierModels for the disease-associated expansion of (CTG) n·(CAG) n,(CGG) n·(CCG) n, and
(GAA) n·(TTC) n trinucleotide repeats involve alternative DNA structures formed during DNA
replication, repair and recombination. These repeat sequences are inherently flexible and
can form a variety of hairpins, intramolecular triplexes, quadruplexes, and slipped-strand
structures that may be important intermediates and result in their genetic instability.
(GAA) n·(TTC) n trinucleotide repeats involve alternative DNA structures formed during DNA
replication, repair and recombination. These repeat sequences are inherently flexible and
can form a variety of hairpins, intramolecular triplexes, quadruplexes, and slipped-strand
structures that may be important intermediates and result in their genetic instability.
Models for the disease-associated expansion of (CTG)n·(CAG)n, (CGG)n·(CCG)n, and (GAA)n·(TTC)n trinucleotide repeats involve alternative DNA structures formed during DNA replication, repair and recombination. These repeat sequences are inherently flexible and can form a variety of hairpins, intramolecular triplexes, quadruplexes, and slipped-strand structures that may be important intermediates and result in their genetic instability.
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