Rapid activation of endothelial NO synthase by estrogen: evidence for a steroid receptor fast-action complex (SRFC) in caveolae
KL Chambliss, PW Shaul - Steroids, 2002 - Elsevier
Estrogen has important atheroprotective and vasoactive properties related to its capacity to
stimulate nitric oxide (NO) production by endothelial NO synthase. Previous work has shown
that these effects are mediated by estrogen receptor (ER) α functioning in a nongenomic
manner via calcium-dependent, MAP kinase-dependent mechanisms. Recent studies have
demonstrated that estradiol (E2) activates eNOS in isolated endothelial plasma membranes
in the absence of added calcium, calmodulin or eNOS cofactors. Studies of blockade by ICI …
stimulate nitric oxide (NO) production by endothelial NO synthase. Previous work has shown
that these effects are mediated by estrogen receptor (ER) α functioning in a nongenomic
manner via calcium-dependent, MAP kinase-dependent mechanisms. Recent studies have
demonstrated that estradiol (E2) activates eNOS in isolated endothelial plasma membranes
in the absence of added calcium, calmodulin or eNOS cofactors. Studies of blockade by ICI …
