Regulation of complement activation by C-reactive protein
C Mold, H Gewurz, TW Du Clos - Immunopharmacology, 1999 - Elsevier
C-reactive protein (CRP) is an acute-phase serum protein and a mediator of innate
immunity. CRP binds to microbial polysaccharides and to ligands exposed on damaged
cells. Binding of CRP to these substrates activates the classical complement pathway
leading to their uptake by phagocytic cells. Complement activation by CRP is restricted to
C1, C4, C2 and C3 with little consumption of C5-9. Surface bound CRP reduces deposition
of and generation of C5b-9 by the alternative pathway and deposition of C3b and lysis by …
immunity. CRP binds to microbial polysaccharides and to ligands exposed on damaged
cells. Binding of CRP to these substrates activates the classical complement pathway
leading to their uptake by phagocytic cells. Complement activation by CRP is restricted to
C1, C4, C2 and C3 with little consumption of C5-9. Surface bound CRP reduces deposition
of and generation of C5b-9 by the alternative pathway and deposition of C3b and lysis by …
