[CITATION][C] Nitric oxide mediates the mitogenic effects of insulin and vascular endothelial growth factor but not of leptin in endothelial cells.
A Józkowicz, J Pankiewicz, J Dulak… - Acta Biochimica …, 1999 - ojs.ptbioch.edu.pl
The regulation of vascular wall homeostasis by nitric oxide (NO) generated by endothelium
is being intensively studied. In the present paper, the involvement of NO in the vascular
endothelial growth factor (VEGF), insulin or leptin-stimulated proliferation of human
endothelial cells (HUVEC) was measured by [3H] thymidine or bromodeoxyuridine
incorporation. VEGF and insulin, but not leptin, increased NO generation in HUVEC, as
detected with ISO-NO electrode. Proliferation of HUVEC induced by leptin was not changed …
is being intensively studied. In the present paper, the involvement of NO in the vascular
endothelial growth factor (VEGF), insulin or leptin-stimulated proliferation of human
endothelial cells (HUVEC) was measured by [3H] thymidine or bromodeoxyuridine
incorporation. VEGF and insulin, but not leptin, increased NO generation in HUVEC, as
detected with ISO-NO electrode. Proliferation of HUVEC induced by leptin was not changed …