Critical role of dipeptidyl peptidase IV in neuropeptide Y-mediated endothelial cell migration in response to wounding
G Ghersi, WT Chen, EW Lee, Z Zukowska - Peptides, 2001 - Elsevier
Recently, we have discovered that neuropeptide Y (NPY), a sympathetic neurotransmitter, is
also present in human umbilical endothelial cells (HUVECs), and is potently chemotactic
and angiogenic by acting on one or several of Y1–Y5 receptors. In HUVECs, NPY is co-
localized with dipeptidyl peptidase IV (DPPIV) which cleaves Tyr1-Pro2 from NPY1–36 to
form NPY3–36 resulting in the formation of a non-Y1 receptor agonist, which remains
angiogenic. Presently we studied the effects of DPPIV's blockade using monoclonal …
also present in human umbilical endothelial cells (HUVECs), and is potently chemotactic
and angiogenic by acting on one or several of Y1–Y5 receptors. In HUVECs, NPY is co-
localized with dipeptidyl peptidase IV (DPPIV) which cleaves Tyr1-Pro2 from NPY1–36 to
form NPY3–36 resulting in the formation of a non-Y1 receptor agonist, which remains
angiogenic. Presently we studied the effects of DPPIV's blockade using monoclonal …
