Plasma neuropeptide Y levels rise in patients undergoing exercise tests for the investigation of chest pain
MJ Morris, JM Elliott, MD Cain, V Kapoor… - Clinical and …, 1986 - Wiley Online Library
MJ Morris, JM Elliott, MD Cain, V Kapoor, MJ West, JP Chalmers
Clinical and experimental pharmacology and physiology, 1986•Wiley Online LibraryNeuropeptide Y (NPY) is colocalised with noradrenaline in post‐ganglionic sympathetic
neurons. In order to examine the possibility that activation of the sympathetic nervous system
might cause release of NPY into the plasma NPY levels were measured in 16 patients
undergoing exercise tests for investigation of chest pain. 2. Plasma NPY concentrations rose
in 14 out of the 16 patients, and the mean level of plasma NPY increased from 335 (sem=
37) to 455 (sem= 41) pg/ml. 3. Plasma noradrenaline and adrenaline levels increased four …
neurons. In order to examine the possibility that activation of the sympathetic nervous system
might cause release of NPY into the plasma NPY levels were measured in 16 patients
undergoing exercise tests for investigation of chest pain. 2. Plasma NPY concentrations rose
in 14 out of the 16 patients, and the mean level of plasma NPY increased from 335 (sem=
37) to 455 (sem= 41) pg/ml. 3. Plasma noradrenaline and adrenaline levels increased four …
Summary
1. Neuropeptide Y (NPY) is colocalised with noradrenaline in post‐ganglionic sympathetic neurons. In order to examine the possibility that activation of the sympathetic nervous system might cause release of NPY into the plasma NPY levels were measured in 16 patients undergoing exercise tests for investigation of chest pain.
2. Plasma NPY concentrations rose in 14 out of the 16 patients, and the mean level of plasma NPY increased from 335 (s.e.m. = 37) to 455 (s.e.m. = 41) pg/ml.
3. Plasma noradrenaline and adrenaline levels increased four‐ and two‐fold respectively.
4. The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated.
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