IL-12/IL-13 axis in allergic asthma
M Wills-Karp - Journal of Allergy and Clinical Immunology, 2001 - Elsevier
Allergic airway diseases are associated with skewed TH2 cytokine production, although the
underlying cause of this aberrant immune response is not well understood. Recently, 2
double-digit cytokines, IL-12 and IL-13, have been proposed to play pivotal roles in the TH2-
polarized immune response to inhaled allergens. IL-12 is a critical determinant of TH1-
mediated immune responses, and it has been shown that deficiency in this cytokine can
lead to TH2-polarized immune responses. IL-13, on the other hand, has recently been …
underlying cause of this aberrant immune response is not well understood. Recently, 2
double-digit cytokines, IL-12 and IL-13, have been proposed to play pivotal roles in the TH2-
polarized immune response to inhaled allergens. IL-12 is a critical determinant of TH1-
mediated immune responses, and it has been shown that deficiency in this cytokine can
lead to TH2-polarized immune responses. IL-13, on the other hand, has recently been …
