Particulate Aspergillus fumigatus antigens elicit a TH2 response in BALB/c mice
VP Kurup, BWP Seymour, H Choi… - Journal of Allergy and …, 1994 - Elsevier
Background: In order to understand the immunoregulation in allergic aspergillosis, a murine
model was developed by exposing animals to particulate and soluble antigens of
Aspergillus fumigatus. Methods: BALB/c mice were exposed to soluble Aspergillus antigen
intranasally. Animals showing moderate levels of IgE were subsequently exposed to soluble
antigen or antigen conjugated to polystyrene beads intranasally. The IgE and IgG 1 in the
sera and the eosinophils in the blood and lungs were studied. The spleen and lung …
model was developed by exposing animals to particulate and soluble antigens of
Aspergillus fumigatus. Methods: BALB/c mice were exposed to soluble Aspergillus antigen
intranasally. Animals showing moderate levels of IgE were subsequently exposed to soluble
antigen or antigen conjugated to polystyrene beads intranasally. The IgE and IgG 1 in the
sera and the eosinophils in the blood and lungs were studied. The spleen and lung …
