IL-4 and IL-5 mRNA expression in induced sputum of asthmatic subjects: comparison with bronchial wash
R Olivenstein, R Taha, EM Minshall… - Journal of allergy and …, 1999 - Elsevier
Background: The local production of TH2-type cytokines is thought to orchestrate the
ongoing eosinophilic inflammation and contribute to the pathophysiologic features of allergic
asthma. Previous studies investigating cytokine expression in asthmatic individuals have
used invasive fiberoptic bronchoscopy techniques. To date, there have been no reports of
cytokine mRNA expression in induced sputum as a means of quantifying local inflammatory
events. Objectives: We examined whether IL-4, IL-5, and IFN-γ mRNA expression could be …
ongoing eosinophilic inflammation and contribute to the pathophysiologic features of allergic
asthma. Previous studies investigating cytokine expression in asthmatic individuals have
used invasive fiberoptic bronchoscopy techniques. To date, there have been no reports of
cytokine mRNA expression in induced sputum as a means of quantifying local inflammatory
events. Objectives: We examined whether IL-4, IL-5, and IFN-γ mRNA expression could be …
