Molecular and cellular mechanisms of allergic disease
DH Broide - Journal of allergy and clinical immunology, 2001 - Elsevier
The molecular and cellular mechanisms mediating the allergic inflammatory cascade
involve multiple mediators, cell types, and pathways. Of particular interest are the pathways
regulated by the TH2 lymphocyte, which result in release of IL-4 (important to IgE synthesis)
and IL-5 (important to eosinophil proliferation). IL-4 regulates differentiation of naïve TH0
cells to develop a TH2 phenotype and stimulates B cells to produce IgE. Cross-linking by
allergen of IgE affixed to high-affinity receptors on mast cells and basophils triggers …
involve multiple mediators, cell types, and pathways. Of particular interest are the pathways
regulated by the TH2 lymphocyte, which result in release of IL-4 (important to IgE synthesis)
and IL-5 (important to eosinophil proliferation). IL-4 regulates differentiation of naïve TH0
cells to develop a TH2 phenotype and stimulates B cells to produce IgE. Cross-linking by
allergen of IgE affixed to high-affinity receptors on mast cells and basophils triggers …
