Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI
KW Moore, P Vieira, DF Fiorentino, ML Trounstine… - Science, 1990 - science.org
KW Moore, P Vieira, DF Fiorentino, ML Trounstine, TA Khan, TR Mosmann
Science, 1990•science.orgComplementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF;
interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and
expressed. The predicted protein sequence shows extensive homology with an
uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting
the possibility that this herpes virus exploits the biological activity of a captured cytokine
gene to enhance its survival in the host.
interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and
expressed. The predicted protein sequence shows extensive homology with an
uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting
the possibility that this herpes virus exploits the biological activity of a captured cytokine
gene to enhance its survival in the host.
Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.
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