[HTML][HTML] Glycosulfopeptides with O-glycans containing sialylated and polyfucosylated polylactosamine bind with low affinity to P-selectin
A Leppänen, L Penttilä, O Renkonen… - Journal of Biological …, 2002 - ASBMB
P-selectin glycoprotein ligand-1 (PSGL-1), a dimeric mucin on leukocytes, is the best
characterized ligand for selectins. P-selectin binds stereospecifically to the extreme N
terminus of PSGL-1, which contains three clustered tyrosine sulfates (TyrSO 3−) adjacent to
a Thr residue with a core 2-based O-glycan expressing sialyl Lewis x (C2-O-sLe x). GSP-6, a
synthetic glycosulfopeptide modeled after the N terminus of PSGL-1, containing three TyrSO
3− residues and a short, monofucosylated C2-O-sLe x bound to P-selectin with high affinity …
characterized ligand for selectins. P-selectin binds stereospecifically to the extreme N
terminus of PSGL-1, which contains three clustered tyrosine sulfates (TyrSO 3−) adjacent to
a Thr residue with a core 2-based O-glycan expressing sialyl Lewis x (C2-O-sLe x). GSP-6, a
synthetic glycosulfopeptide modeled after the N terminus of PSGL-1, containing three TyrSO
3− residues and a short, monofucosylated C2-O-sLe x bound to P-selectin with high affinity …