The microbial product lipopolysaccharide confers diabetogenic potential on the T cell repertoire of BDC2. 5/NOD mice: implications for the etiology of autoimmune …
B Balasa, K Van Gunst, N Sarvetnick - Clinical Immunology, 2000 - Elsevier
Both genetic predisposition and environmental factors participate in the etiology of Type-1
diabetes. To test the role of the microbial product lipopolysaccharide (LPS) as an
environmental trigger of autoimmune diabetes, we employed transgenic (tg) BDC2. 5/NOD
mice that bear an islet-specific CD4+ T cell repertoire (> 95%), but do not develop the
spontaneous diabetes that typifies the NOD (nonobese diabetic) strain. LPS administration
provoked diabetes in BDC2. 5/NOD mice by their 16th week of age. However, LPS …
diabetes. To test the role of the microbial product lipopolysaccharide (LPS) as an
environmental trigger of autoimmune diabetes, we employed transgenic (tg) BDC2. 5/NOD
mice that bear an islet-specific CD4+ T cell repertoire (> 95%), but do not develop the
spontaneous diabetes that typifies the NOD (nonobese diabetic) strain. LPS administration
provoked diabetes in BDC2. 5/NOD mice by their 16th week of age. However, LPS …