The search for IDDM susceptibility genes: the next generation
D Owerbach, KH Gabbay - Diabetes, 1996 - Am Diabetes Assoc
Diabetes, 1996•Am Diabetes Assoc
Two human chromosomal regions, the HLA region on chromosome 6p21 and the insulin
gene region on chromosome 11p15, have been investigated in detail for more than 10 years
for the presence of IDDM susceptibility genes. Recent genome searches indicate the
possible existence of many additional susceptibility genes in IDDM. The lengthy and
protracted studies to prove the linkage and identity of the susceptibility genes in the HLA and
insulin gene regions provide a perspective and background for understanding the …
gene region on chromosome 11p15, have been investigated in detail for more than 10 years
for the presence of IDDM susceptibility genes. Recent genome searches indicate the
possible existence of many additional susceptibility genes in IDDM. The lengthy and
protracted studies to prove the linkage and identity of the susceptibility genes in the HLA and
insulin gene regions provide a perspective and background for understanding the …
Two human chromosomal regions, the HLA region on chromosome 6p21 and the insulin gene region on chromosome 11p15, have been investigated in detail for more than 10 years for the presence of IDDM susceptibility genes. Recent genome searches indicate the possible existence of many additional susceptibility genes in IDDM. The lengthy and protracted studies to prove the linkage and identity of the susceptibility genes in the HLA and insulin gene regions provide a perspective and background for understanding the complexities and time course for characterization of the putative additional IDDM susceptibility genes uncovered by genome searches.
Am Diabetes Assoc