Stimulation of osteoclastic bone resorption by hydrogen peroxide
BE Bax, ASMT Alam, B Banerji, CMR Bax… - Biochemical and …, 1992 - Elsevier
BE Bax, ASMT Alam, B Banerji, CMR Bax, PJR Bevis, CR Stevens, BS Moonga, DR Blake…
Biochemical and biophysical research communications, 1992•ElsevierThe molecular mechanisms underlying the pathophysiology of bone destruction still remain
poorly understood. We have found that hydrogen peroxide (H 2 O 2), a reactive oxygen
species (ROS), is a potent stimulator of osteoclastic bone resorption and cell motility. A
marked enhancement of bone resorption was noted when rat osteoclasts, cultured on
devitalised bovine cortical bone, were exposed to 10 nM [H 2 O 2]. Apart from exposing
osteoclasts to a low extracellular pH, which is known to enhance osteoclastic bone …
poorly understood. We have found that hydrogen peroxide (H 2 O 2), a reactive oxygen
species (ROS), is a potent stimulator of osteoclastic bone resorption and cell motility. A
marked enhancement of bone resorption was noted when rat osteoclasts, cultured on
devitalised bovine cortical bone, were exposed to 10 nM [H 2 O 2]. Apart from exposing
osteoclasts to a low extracellular pH, which is known to enhance osteoclastic bone …
The molecular mechanisms underlying the pathophysiology of bone destruction still remain poorly understood. We have found that hydrogen peroxide (H2O2), a reactive oxygen species (ROS), is a potent stimulator of osteoclastic bone resorption and cell motility. A marked enhancement of bone resorption was noted when rat osteoclasts, cultured on devitalised bovine cortical bone, were exposed to 10 nM [H2O2]. Apart from exposing osteoclasts to a low extracellular pH, which is known to enhance osteoclastic bone resorption, we provide first evidence for a molecule that stimulates osteoclastic bone resorption in osteoclast cultures that do not respond to parathyroid hormone and 1, 25 dihydroxyvitamin D3. We envisage that both basic biological and practical clinical implications may eventually follow from these studies.
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