Thioredoxin, a dithiol polypeptide, has been examined as a potential contributor to the
recovery of lens epithelial cells from oxidative insult. It is reported that Escherichia coli
thioredoxin can (a) effectively reduce lens-soluble protein disulfide bonds generated by
H2O2,(b) restore to its initial activity H2O2-inactivated glyceraldehyde-3-phosphate
dehydrogenase,(c) act as an effective source of reducing potential for lens methionine
sulfoxide peptide reductase, and (d) act as a free radical quencher based on studies with a …