Injury and repair in lung and airways
DW Shimabukuro, T Sawa, MA Gropper - Critical care medicine, 2003 - journals.lww.com
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common causes
of morbidity and mortality in the intensive care unit. ALI/ARDS occurs as a result of systemic
inflammation, usually triggered by a microorganism. Activation of leukocytes and release of
proinflammatory mediators from multiple cellular sources result in both local and distant
tissue injury. Tumor necrosis factor-α and interleukin-1β are the best characterized of the
proinflammatory cytokines contributing to ALI/ARDS and subsequent fibrosis. The ultimate …
of morbidity and mortality in the intensive care unit. ALI/ARDS occurs as a result of systemic
inflammation, usually triggered by a microorganism. Activation of leukocytes and release of
proinflammatory mediators from multiple cellular sources result in both local and distant
tissue injury. Tumor necrosis factor-α and interleukin-1β are the best characterized of the
proinflammatory cytokines contributing to ALI/ARDS and subsequent fibrosis. The ultimate …