Multiple sclerosis (MS) is a presumed autoimmune disease of the central nervous system.
Inoculation of attenuated T cell clones recognizing immunodominant regions of myelin
autoantigens can protect animals from the induction of experimental autoimmune diseases.
In this phase one trial, we investigated whether inoculations with attenuated T cell clones
are feasible in humans for eventual trials with autoreactive clones and whether there are any
associated immunologic effects. A total of seven inoculations with attenuated, autologous T …