Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis
GL Boccaccio, F Mor, L Steinman - International Immunology, 1999 - academic.oup.com
GL Boccaccio, F Mor, L Steinman
International Immunology, 1999•academic.oup.comRegulatory sequences used in plasmids for naked DNA vaccination can modulate cytokine
production in vivo. We demonstrate here that injection of plasmid DNA can suppress the
prototypic T cell-mediated autoimmune disease, experimental autoimmune
encephalomyelitis, by inducing IFN-γ.
production in vivo. We demonstrate here that injection of plasmid DNA can suppress the
prototypic T cell-mediated autoimmune disease, experimental autoimmune
encephalomyelitis, by inducing IFN-γ.
Abstract
Regulatory sequences used in plasmids for naked DNA vaccination can modulate cytokine production in vivo. We demonstrate here that injection of plasmid DNA can suppress the prototypic T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis, by inducing IFN-γ.
Oxford University Press