Characterization of a cDNA encoding murine coagulation factor VII
E Idusogie, E Rosen, JP Geng… - Thrombosis and …, 1996 - thieme-connect.com
E Idusogie, E Rosen, JP Geng, P Carmeliet, D Collen, FJ Castellino
Thrombosis and haemostasis, 1996•thieme-connect.comThe cDNA encoding murine coagulation factor VII (mfVII) was isolated and reconstructed
from a Λ Zap cDNA library generated from murine liver mRNA. The cDNA contains 1903
nucleotides spanning 15 bases upstream of the 5'-translation initiation codon, an open
reading frame of 1338 nucleotides, 550 nucleotides downstream of the first stop codon and
a 3'poly (A) tail. The translation product is composed of a 41-amino acid signal/propeptide
region followed by a 405-residue mature protein. The latter is highly homologous to that of …
from a Λ Zap cDNA library generated from murine liver mRNA. The cDNA contains 1903
nucleotides spanning 15 bases upstream of the 5'-translation initiation codon, an open
reading frame of 1338 nucleotides, 550 nucleotides downstream of the first stop codon and
a 3'poly (A) tail. The translation product is composed of a 41-amino acid signal/propeptide
region followed by a 405-residue mature protein. The latter is highly homologous to that of …
The cDNA encoding murine coagulation factor VII (mfVII) was isolated and reconstructed from a Λ Zap cDNA library generated from murine liver mRNA. The cDNA contains 1903 nucleotides spanning 15 bases upstream of the 5’-translation initiation codon, an open reading frame of 1338 nucleotides, 550 nucleotides downstream of the first stop codon and a 3’ poly(A) tail. The translation product is composed of a 41-amino acid signal/propeptide region followed by a 405-residue mature protein. The latter is highly homologous to that of human, rabbit, bovine, Rhesus monkey, and canine fVII. All protein domains of hfVII are strictly conserved in mfVII.
Thieme Connect