Lymphotoxin β, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface
JL Browning, A Ngam-ek, P Lawton, J DeMarinis… - Cell, 1993 - cell.com
JL Browning, A Ngam-ek, P Lawton, J DeMarinis, R Tizard, EP Chow, C Hession…
Cell, 1993•cell.comThe lymphokine tumor necrosis factor (TNF) has a well-defined role as an inducer of
inflammatory responses; however, the function of the structurally related molecule
lymphotoxin (LTa) is unknown. LTa is present on the surface of activated T, B, and LAK cells
as a complex with a 33 kd glycoprotein, and cloning of the cDNA encoding the associated
protein, called lymphotoxin p (LTP), revealed it to be a type II membrane protein with
significant homology to TNF, LTa, and the ligand for the CD40 receptor. The gene for LTP …
inflammatory responses; however, the function of the structurally related molecule
lymphotoxin (LTa) is unknown. LTa is present on the surface of activated T, B, and LAK cells
as a complex with a 33 kd glycoprotein, and cloning of the cDNA encoding the associated
protein, called lymphotoxin p (LTP), revealed it to be a type II membrane protein with
significant homology to TNF, LTa, and the ligand for the CD40 receptor. The gene for LTP …
Summary
The lymphokine tumor necrosis factor (TNF) has a well-defined role as an inducer of inflammatory responses; however, the function of the structurally related molecule lymphotoxin (LTa) is unknown. LTa is present on the surface of activated T, B, and LAK cells as a complex with a 33 kd glycoprotein, and cloning of the cDNA encoding the associated protein, called lymphotoxin p (LTP), revealed it to be a type II membrane protein with significant homology to TNF, LTa, and the ligand for the CD40 receptor. The gene for LTP was found next to the TNF-LT locus in the major histocompatibilitycomplex(MHC), a region of the MHC with possible linkage to autoimmune disease. These observations raise the possibility that a surface LTa-LTP complex may have a specific role in immune regulation distinct from the functions ascribed to TNF.
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