[HTML][HTML] Gene expression in scrapie: cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts
F Dandoy-Dron, F Guillo, L Benboudjema… - Journal of Biological …, 1998 - ASBMB
To define genes associated with or responsible for the neurodegenerative changes
observed in transmissible spongiform encephalopathies, we analyzed gene expression in
scrapie-infected mouse brain using" mRNA differential display." The RNA transcripts of eight
genes were increased 3–8-fold in the brains of scrapie-infected animals. Five of these genes
have not previously been reported to exhibit increased expression in this disease: cathepsin
S, the C1q B-chain of complement, apolipoprotein D, and two previously unidentified genes …
observed in transmissible spongiform encephalopathies, we analyzed gene expression in
scrapie-infected mouse brain using" mRNA differential display." The RNA transcripts of eight
genes were increased 3–8-fold in the brains of scrapie-infected animals. Five of these genes
have not previously been reported to exhibit increased expression in this disease: cathepsin
S, the C1q B-chain of complement, apolipoprotein D, and two previously unidentified genes …