[HTML][HTML] Calcium stabilizes fibrillin-1 against proteolytic degradation
DP Reinhardt, RN Ono, LY Sakai - Journal of Biological Chemistry, 1997 - ASBMB
The calcium-binding epidermal growth factor (cbEGF)-like domain is a structural motif that is
present in many matrix proteins throughout the animal kingdom from invertebrates to
mammals. This module has been demonstrated to bind calcium in the micromolar range.
However, little is known about the functional consequences of calcium binding to proteins
that contain this structural element. We used fibrillin-1, an extracellular matrix protein
consisting of∼ 60% cbEGF-like motifs, as a model system to study stabilizing effects of …
present in many matrix proteins throughout the animal kingdom from invertebrates to
mammals. This module has been demonstrated to bind calcium in the micromolar range.
However, little is known about the functional consequences of calcium binding to proteins
that contain this structural element. We used fibrillin-1, an extracellular matrix protein
consisting of∼ 60% cbEGF-like motifs, as a model system to study stabilizing effects of …