[HTML][HTML] The Interferon-γ-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro (∗)
M Groettrup, T Ruppert, L Kuehn, M Seeger… - Journal of Biological …, 1995 - ASBMB
Antigenic peptides presented on major histocompatibility complex (MHC) class I molecules
to cytotoxic T cells are generated in the cytosol by the 20 S proteasome. Upon stimulation of
antigen presenting cells with interferon-γ, two constitutive subunits of the 20 S proteasome
are replaced by the MHC-encoded subunits low molecular mass polypeptide (LMP) 2 and
LMP 7. In addition the expression of the two subunits of the 11 S regulator of the 20 S
proteasome (PA28) are increased. As the function of LMP2 and LMP7 in antigen …
to cytotoxic T cells are generated in the cytosol by the 20 S proteasome. Upon stimulation of
antigen presenting cells with interferon-γ, two constitutive subunits of the 20 S proteasome
are replaced by the MHC-encoded subunits low molecular mass polypeptide (LMP) 2 and
LMP 7. In addition the expression of the two subunits of the 11 S regulator of the 20 S
proteasome (PA28) are increased. As the function of LMP2 and LMP7 in antigen …
