Spontaneous thyroiditis in thymectomized and irradiated Wistar rats
WJ Penhale, A Farmer, RP McKenna… - Clinical and …, 1973 - ncbi.nlm.nih.gov
WJ Penhale, A Farmer, RP McKenna, WJ Irvine
Clinical and experimental immunology, 1973•ncbi.nlm.nih.govThyroiditis and autoantibodies to thyroglobulin were found to develop spontaneously in 60%
of randomly bred Wistar rats subjected to thymectomy and whole body irradiation after
weaning. Antinuclear antibodies were found in approximately 10% of these animals.
Thyroiditis was seen in rats which were whole body irradiated without thymectomy but at a
much lower incidence (22%). Control rats given irradiation to the thyroid region alone
showed no such effects. The histology of the thyroid gland was similar to that seen in …
of randomly bred Wistar rats subjected to thymectomy and whole body irradiation after
weaning. Antinuclear antibodies were found in approximately 10% of these animals.
Thyroiditis was seen in rats which were whole body irradiated without thymectomy but at a
much lower incidence (22%). Control rats given irradiation to the thyroid region alone
showed no such effects. The histology of the thyroid gland was similar to that seen in …
Abstract
Thyroiditis and autoantibodies to thyroglobulin were found to develop spontaneously in 60% of randomly bred Wistar rats subjected to thymectomy and whole body irradiation after weaning. Antinuclear antibodies were found in approximately 10% of these animals. Thyroiditis was seen in rats which were whole body irradiated without thymectomy but at a much lower incidence (22%). Control rats given irradiation to the thyroid region alone showed no such effects. The histology of the thyroid gland was similar to that seen in Hashimoto thyroiditis in man.
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