T lymphocyte lines producing or vaccinating against autoimmune encephalomyelitis (EAE). Functional activation induces peanut agglutinin receptors and …
Y Naparstek, A Ben‐Nun, J Holoshitz… - European journal of …, 1983 - Wiley Online Library
Y Naparstek, A Ben‐Nun, J Holoshitz, T Reshef, A Frenkel, M Rosenberg, IR Cohen
European journal of immunology, 1983•Wiley Online LibraryWe studied lines of rat T cells, specifically reactive against myelin basic protein (BP), that
were functional in mediating autoimmune encephalomyelitis or in vaccinating rats against
induction of active EAE. Herein we report that these functions depended on activation of the
cells by incubation with BP or with a T cell mitogen prior to inoculation into recipient rats.
Activation was accompanied by the exposure of membrane‐binding sites specific for the
lectin peanut agglutinin. Accumulation of activated line cells in the central nervous system …
were functional in mediating autoimmune encephalomyelitis or in vaccinating rats against
induction of active EAE. Herein we report that these functions depended on activation of the
cells by incubation with BP or with a T cell mitogen prior to inoculation into recipient rats.
Activation was accompanied by the exposure of membrane‐binding sites specific for the
lectin peanut agglutinin. Accumulation of activated line cells in the central nervous system …
Abstract
We studied lines of rat T cells, specifically reactive against myelin basic protein (BP), that were functional in mediating autoimmune encephalomyelitis or in vaccinating rats against induction of active EAE. Herein we report that these functions depended on activation of the cells by incubation with BP or with a T cell mitogen prior to inoculation into recipient rats. Activation was accompanied by the exposure of membrane‐binding sites specific for the lectin peanut agglutinin. Accumulation of activated line cells in the central nervous system and thymus gland was observed.
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