Stimulation of human T lymphocytes by PHA-activated autologous T lymphocytes: analysis of the role of Ia-like antigens with monoclonal antibodies
C Russo, F Indiveri, V Quaranta, GA Molinaro… - Immunogenetics, 1981 - Springer
C Russo, F Indiveri, V Quaranta, GA Molinaro, MA Pellegrino, S Ferrone
Immunogenetics, 1981•SpringerHuman T lymphocytes activated with PHA express Ia-like antigens and acquire the ability to
stimulate autologous T lymphocytes in mixed lymphocyte reaction. This reaction is
immunological in nature since it has specificity and memory. Ia-like antigens play a role in
the stimulation of T lymphocytes by autologous PHA-T lymphocytes since monoclonal
antibodies to Ia-like antigens can significantly, although not completely, inhibit the
stimulation.
stimulate autologous T lymphocytes in mixed lymphocyte reaction. This reaction is
immunological in nature since it has specificity and memory. Ia-like antigens play a role in
the stimulation of T lymphocytes by autologous PHA-T lymphocytes since monoclonal
antibodies to Ia-like antigens can significantly, although not completely, inhibit the
stimulation.
Abstract
Human T lymphocytes activated with PHA express Ia-like antigens and acquire the ability to stimulate autologous T lymphocytes in mixed lymphocyte reaction. This reaction is immunological in nature since it has specificity and memory. Ia-like antigens play a role in the stimulation of T lymphocytes by autologous PHA-T lymphocytes since monoclonal antibodies to Ia-like antigens can significantly, although not completely, inhibit the stimulation.
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