KSR-1 binds to G-protein βγ subunits and inhibits βγ-induced mitogen-activated protein kinase activation
B Bell, H Xing, K Yan, N Gautam, AJ Muslin - Journal of Biological …, 1999 - ASBMB
The protein kinase KSR-1 is a recently identified participant in the Ras signaling pathway.
The subcellular localization of KSR-1 is variable. In serum-deprived cultured cells, KSR-1 is
primarily found in the cytoplasm; in serum-stimulated cells, a significant portion of KSR-1 is
found at the plasma membrane. To identify the mechanism that mediates KSR-1
translocation, we performed a yeast two-hybrid screen. Three clones that interacted with
KSR-1 were found to encode the full-length γ 10 subunit of heterotrimeric G-proteins. KSR-1 …
The subcellular localization of KSR-1 is variable. In serum-deprived cultured cells, KSR-1 is
primarily found in the cytoplasm; in serum-stimulated cells, a significant portion of KSR-1 is
found at the plasma membrane. To identify the mechanism that mediates KSR-1
translocation, we performed a yeast two-hybrid screen. Three clones that interacted with
KSR-1 were found to encode the full-length γ 10 subunit of heterotrimeric G-proteins. KSR-1 …
