The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK
HR Xing, L Campodonico, R Kolesnick - Journal of Biological Chemistry, 2004 - ASBMB
Kinase Suppressor of Ras1 (KSR1) functions as a positive modulator of Ras-dependent
signaling either upstream of or parallel to Raf-1, and pharmacologic inactivation of KSR1
may serve as a treatment for Rasdriven malignancies such as pancreatic cancer (Xing, HR,
Cordon-Cardo, C., Deng, X., Tong, W., Campodonico, L., Fuks, Z., and Kolesnick, R.(2003)
Nat. Med. 9, 1266–1268). Although some studies demonstrated a requirement for KSR1
kinase activity for its action, others suggested KSR1 acts primarily as a scaffold facilitating …
signaling either upstream of or parallel to Raf-1, and pharmacologic inactivation of KSR1
may serve as a treatment for Rasdriven malignancies such as pancreatic cancer (Xing, HR,
Cordon-Cardo, C., Deng, X., Tong, W., Campodonico, L., Fuks, Z., and Kolesnick, R.(2003)
Nat. Med. 9, 1266–1268). Although some studies demonstrated a requirement for KSR1
kinase activity for its action, others suggested KSR1 acts primarily as a scaffold facilitating …
