Acquired resistance to acute oxidative stress. Possible role of heme oxygenase and ferritin.
BA Vogt, J Alam, AJ Croatt, GM Vercellotti… - … investigation; a journal …, 1995 - europepmc.org
BA Vogt, J Alam, AJ Croatt, GM Vercellotti, KA Nath
Laboratory investigation; a journal of technical methods and pathology, 1995•europepmc.orgBackground Prior administration of endotoxin has conferred resistance to tissue damage in
a number of models of organ injury. The mechanisms by which this resistance is conferred
are enigmatic. Recognizing that enhanced tissue oxidative stress may be a feature of
endotoxin-associated injury and is present in many models of tissue injury, we questioned
whether the beneficial effect conferred by endotoxin is dependent on the up-regulation of
antioxidant defenses.
a number of models of organ injury. The mechanisms by which this resistance is conferred
are enigmatic. Recognizing that enhanced tissue oxidative stress may be a feature of
endotoxin-associated injury and is present in many models of tissue injury, we questioned
whether the beneficial effect conferred by endotoxin is dependent on the up-regulation of
antioxidant defenses.
Background
Prior administration of endotoxin has conferred resistance to tissue damage in a number of models of organ injury. The mechanisms by which this resistance is conferred are enigmatic. Recognizing that enhanced tissue oxidative stress may be a feature of endotoxin-associated injury and is present in many models of tissue injury, we questioned whether the beneficial effect conferred by endotoxin is dependent on the up-regulation of antioxidant defenses.
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