[HTML][HTML] Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras
HR Xing, J Lozano, R Kolesnick - Journal of Biological Chemistry, 2000 - ASBMB
In Drosophila melanogaster andCaenorhabditis elegans, kinasesuppressor of Ras (KSR)
functions as a positive modulator of Ras-dependent signaling either upstream of or parallel
to Raf. Attempts to characterize the biochemical and biological properties of mammalian
KSR, however, have had limited success. Although some studies demonstrated a
requirement of KSR kinase activity for its action, others indicated the kinase function of KSR
is dispensable and suggested that KSR acts primarily as a scaffold protein. Interpretations of …
functions as a positive modulator of Ras-dependent signaling either upstream of or parallel
to Raf. Attempts to characterize the biochemical and biological properties of mammalian
KSR, however, have had limited success. Although some studies demonstrated a
requirement of KSR kinase activity for its action, others indicated the kinase function of KSR
is dispensable and suggested that KSR acts primarily as a scaffold protein. Interpretations of …