Mast cells and tumor angiogenesis
DA Kessler, RS Langer, NA Pless… - International Journal of …, 1976 - Wiley Online Library
DA Kessler, RS Langer, NA Pless, J Folkman
International Journal of Cancer, 1976•Wiley Online LibraryTumor angiogenesis factor (TAF) elicits a strong vasoproliferative response when implanted
upon the chorioallantoic membrane (CAM) of the chick embryo. This response is first
observed stereomicroscopically 2–3 days after implantation. A 40‐fold increase in mast cell
density is observed within the vicinity of this implant by 24 h. Mast cells that have been
isolated from retired breeder Sprague‐Dawley rats fail to evoke a vascular reaction when
implanted on the CAM. An intermediate role for the mast cell in tumor angiogenesis is …
upon the chorioallantoic membrane (CAM) of the chick embryo. This response is first
observed stereomicroscopically 2–3 days after implantation. A 40‐fold increase in mast cell
density is observed within the vicinity of this implant by 24 h. Mast cells that have been
isolated from retired breeder Sprague‐Dawley rats fail to evoke a vascular reaction when
implanted on the CAM. An intermediate role for the mast cell in tumor angiogenesis is …
Abstract
Tumor angiogenesis factor (TAF) elicits a strong vasoproliferative response when implanted upon the chorioallantoic membrane (CAM) of the chick embryo. This response is first observed stereomicroscopically 2–3 days after implantation. A 40‐fold increase in mast cell density is observed within the vicinity of this implant by 24 h. Mast cells that have been isolated from retired breeder Sprague‐Dawley rats fail to evoke a vascular reaction when implanted on the CAM. An intermediate role for the mast cell in tumor angiogenesis is suggested.
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