Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma
British Journal of Cancer, 1999•nature.com
Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis
and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple
myeloma (MM) compared with 34 patients with non-active MM and 22 patients with
monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that
angiogenesis parallels progression of MM, and that MCs participate in its induction via
angiogenic factors in their secretory granules.
and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple
myeloma (MM) compared with 34 patients with non-active MM and 22 patients with
monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that
angiogenesis parallels progression of MM, and that MCs participate in its induction via
angiogenic factors in their secretory granules.
Summary
Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that angiogenesis parallels progression of MM, and that MCs participate in its induction via angiogenic factors in their secretory granules.
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