Induction of Plasma-Cell Neoplasms in Strain BALB/c Mice with Mineral Oil and Mineral Oil Adjuvants
M Potter, CR Boyce - Nature, 1962 - nature.com
M Potter, CR Boyce
Nature, 1962•nature.comMerwin and Algire1 have reported the development of plasma-cell neoplasms in strain
BALB/c mice which had been implanted intraperitoneally with 'Millipore'diffusion chambers.
We have observed plasma-cell neoplasms in the same strain of mice after intraperitoneal
injection of a mixture of incomplete Freund's adjuvants and heat-killed Staphylococcus
cultures2. In other experiments, reported here, we sought to determine:(1) the frequency of
plasma-cell neoplasms in mice injected with the adjuvant–Staphylococcus mixture;(2) if the …
BALB/c mice which had been implanted intraperitoneally with 'Millipore'diffusion chambers.
We have observed plasma-cell neoplasms in the same strain of mice after intraperitoneal
injection of a mixture of incomplete Freund's adjuvants and heat-killed Staphylococcus
cultures2. In other experiments, reported here, we sought to determine:(1) the frequency of
plasma-cell neoplasms in mice injected with the adjuvant–Staphylococcus mixture;(2) if the …
Abstract
Merwin and Algire1 have reported the development of plasma-cell neoplasms in strain BALB/c mice which had been implanted intraperitoneally with ‘Millipore’ diffusion chambers. We have observed plasma-cell neoplasms in the same strain of mice after intraperitoneal injection of a mixture of incomplete Freund's adjuvants and heat-killed Staphylococcus cultures2. In other experiments, reported here, we sought to determine: (1) the frequency of plasma-cell neoplasms in mice injected with the adjuvant–Staphylococcus mixture; (2) if the whole mixture was necessary.
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