BACKGROUND: Among atopic individuals, levels of allergen-specific IgG antibodies have
been inversely associated with the degree of allergen sensitization. Additionally, allergen-
specific IgG antibodies are markedly increased by allergen injection immunotherapy. These
observations have led to proposals that allergen-specific IgG antibodies might have
protective properties in atopic individuals. OBJECTIVE: We hypothesized that after grass
pollen immunotherapy, these antibodies disrupt IgE-dependent allergen processing by …